BEGIN:VCALENDAR
VERSION:2.0
PRODID:Icfo
X-PUBLISHED-TTL:P1W
BEGIN:VEVENT
UID:69d58543483ef
DTSTART:20241218T110000Z
SEQUENCE:0
TRANSP:OPAQUE
DTEND:20241218T120000Z
LOCATION:Auditorium
SUMMARY:ICFO | ROMAIN QUIDANT
CLASS:PUBLIC
DESCRIPTION:ABSTRACT:\nBiosensing technologies aim to detect bioanalytes wi
 thin complex biological matrices\, providing invaluable tools for addressi
 ng fundamental biological questions\, diagnosing diseases\, and monitoring
  treatment efficacy. A long-standing goal in this field is to achieve labe
 l-free\, high-throughput detection of multiple analytes within complex mat
 rices. In this presentation\, we discuss how the versatile technique of di
 gital holography can significantly contribute to this objective through th
 ree different optofluidic platforms.\nMultiplexed Label-Free Immunoaffinit
 y Assay - We introduce an optofluidic platform that integrates state-of-th
 e-art digital holography with PDMS microfluidics\, utilizing supported lip
 id bilayers as a versatile surface chemistry building block. This platform
  enables the label-free\, single-particle-sensitive fingerprinting of hete
 rogeneous extracellular vesicle populations through a multiplexed immunoaf
 finity assay. We demonstrate the potential of this approach to extend beyo
 nd extracellular vesicles to single proteins.\nWide-Field\, Spectrally Res
 olved Optical Activity Imaging - Beyond simple detection\, digital hologra
 phy can provide additional insights into biomolecular properties. By emplo
 ying polarization-sensitive off-axis holography\, our system enables singl
 e-shot retrieval of circular dichroism (CD) and optical rotatory dispersio
 n (ORD) images. This approach not only aligns with traditional CD spectros
 copy but also offers the unique capability to spatially resolve local chir
 ality variations that are often obscured by ensemble averaging.\nDynamic\,
  Reconfigurable Fluidic Boundaries - We present a novel optofluidic toolbo
 x that harnesses structured light and photothermal conversion to create dy
 namic\, reconfigurable fluidic boundaries. This system enables precise man
 ipulation of fluids and particles by generating 3D thermal landscapes with
  high spatial control. Our approach mimics the functions of traditional ph
 ysical barriers while offering the advantage of real-time reconfiguration 
 for complex tasks\, such as individual particle steering and size-based so
 rting in heterogeneous mixtures. This versatile platform has the potential
  to revolutionize microfluidic systems\, finding applications in chemical 
 synthesis\, lab-on-chip devices\, and microbiology.
DTSTAMP:20260407T222923Z
END:VEVENT
END:VCALENDAR