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DTSTART:20250922T100000Z
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LOCATION:Seminar Room
SUMMARY:ICFO | GIULIA GIUBERTONI 
CLASS:PUBLIC
DESCRIPTION:We present a method to simultaneously characterize molecular st
 ructure and size: Optical Diffusion-Ordered SpectroscopY (Optical-DOSY).[1
 -4] This method is inspired by concepts from NMR\, and relies on the fact 
 that the diffusion coefficient of a particle is determined by its size thr
 ough the Stokes-Einstein relation.\nIn our approach\, we create a step-fun
 ction concentration profile inside an optical sample cell. By measuring th
 e time-dependent absorption spectrum in an initially solvent-filled part o
 f the sample volume\, we obtain the diffusion coefficients and the optical
  spectra of the species present in the sample solution. Since the diffusio
 n coefficient is inversely proportional to the hydrodynamic radius R throu
 gh the Stokes-Einstein relation\, we extract simultaneously size and chemi
 cal information. From these data\, we construct a two-dimensional spectrum
  with absorption wavelength/frequency on one axis and size on the other\, 
 in which the optical spectrum of a mixture with different molecular sizes 
 is separated into the spectra of the different species\, sorted by size. W
 e have demonstrated its feasibility using infrared spectroscopy (IR)[1\,2]
 \, and later using Raman and UV/Vis spectroscopy[3-4]\, demonstrating the 
 broad versatility of our technology. We have also developed and validated 
 in-house prototypes of chips that can be easily integrated with common spe
 ctrometers. In this way\, anyone can add size-sensitivity to their IR\, UV
 /Vis or Raman spectrometer.\n[1] Infrared Diffusion‐Ordered Spectroscopy
  Reveals Molecular Size and Structure\, Giubertoni et. al.\, Angewandte Ch
 emie\, 2023[2] Multidimensional infrared diffusion-ordered spectroscopy in
  depletion mode distinguishes protein amyloids and monomers\, Giubertoni e
 t al.\, JCP\, 2023[3] Raman Diffusion-Ordered Spectroscopy\, Schmidt et al
 \, 2023\, JPCA\, 2023[4] Optical Diffusion-Ordered Spectroscopy: A Simulta
 neous Probe of Molecular Size and UV/Visible Absorption\, Analytical Chemi
 stry\, 2024
DTSTAMP:20260517T041021Z
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